Yazar "İlter, Metehan" için listeleme
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Dimethyl sulfoxide reduces the stability but enhances catalytic activity of the main SARS-CoV-2 protease 3CLpro
Ferreira, Juliana C.; Fadl, Samar; İlter, Metehan; Pekel, Hanife; Rezgui, Rachid; Şensoy, Özge; Rabeh, Wael M. (John Wiley and Sons Inc, 2021)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19), one of the most challenging global pandemics of the modern era. Potential treatment strategies against ... -
Inhibition of mutant RAS-RAF interaction by mimicking structural and dynamic properties of phosphorylated RAS
İlter, Metehan; Kaşmer, Ramazan; Jalalypour, Farzaneh; Atılgan, Canan; Topçu, Ozan; Karakaş, Nihal; Şensoy, Özge (NLM (Medline), 2022)Undruggability of RAS proteins has necessitated alternative strategies for the development of effective inhibitors. In this respect, phosphorylation has recently come into prominence as this reversible post-translational ... -
Inhibition of SARS-CoV-2 main protease: A repurposing study that targets the dimer interface of the protein
Pekel, Hanife; İlter, Metehan; Şensoy, Özge (Taylor and Francis Ltd., 2022)Coronavirus disease-2019 (COVID-19) was firstly reported in Wuhan, China, towards the end of 2019, and emerged as a pandemic. The spread and lethality rates of the COVID-19 have ignited studies that focus on the development ... -
Utilization of biased G protein-coupled receptor signaling towards development of safer and personalized therapeutics
İlter, Metehan; Mansoor, Samman; Şensoy, Özge (MDPI, 2019)G protein-coupled receptors (GPCRs) are involved in a wide variety of physiological processes. Therefore, approximately 40% of currently prescribed drugs have targeted this receptor family. Discovery of beta-arrestin ...